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Patients with aortic stenosis who are not candidates for surgery and present with pulmonary congestion may be treated with digoxin.

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Digoxin reduces catecholamine reuptake at nerve terminals, rendering blood vessels more sensitive to endogenous or exogenous catecholamines.

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Digoxin is described chemically as 3 , 5 , 12 -3- o -2, 6-dideoxy- – d-ribo -hexopyranosyl- 1 4 -o-2,6-dideoxy- – d-ribo -hexopyranosyl- 1 4 -2,6-dideoxy- -d-ribo-hexopyranosyl oxy -12,14-dihydroxy-card-20 22 -enolide.

Concurrent use of amiodarone, amlodipine, colchicine, digoxin, diltiazem, and lipid-modifying dosages 1 g day or more of niacincontaining products, other fibrates, ranolazine, verapamil, or warfarin.

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There is an increased risk of atrioventricular block and bradycardia when digoxin and beta blockers are taken concomitantly.

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olsalazine moderate mesalamine, the metabolite of olsalazine, can decrease the gi absorption of digoxin.


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Several reports of possible interference with digoxin radioimmunoassay by aldactone, or its metabolites, have appeared in the literature.

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